ina-1 Integrin alpha ina-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ina-1
Official Full Name: Integrin alpha ina-1
Primary source: WormBase:WBGene00002081
Locus tag: CELE_F54G8.3
See related: AllianceGenome:WB:WBGene00002081
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables transmembrane signaling receptor activity. Involved in several processes, including cell-cell adhesion mediated by integrin; generation of neurons; and nematode male tail tip morphogenesis. Located in phagocytic cup. Part of integrin complex. Is expressed in several structures, including ABplaapppp; hermaphrodite gonad; neurons; ventral nerve cord; and vulE. Used to study cancer and epilepsy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; junctional epidermolysis bullosa; junctional epidermolysis bullosa with pyloric atresia; and muscular disease. Orthologous to several human genes including ITGA6 (integrin subunit alpha 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ina-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (9168073..9172802, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, the cytoplasmic tails of alpha integrins can bypass signaling from members of the Rho family of GTPases during development.
Title: α integrin cytoplasmic tails can rescue the loss of Rho-family GTPase signaling in the C. elegans somatic gonad.
The transcription factor hlh-2 is required for up-regulation of ina-1 at the onset of distal tip cell migration.
Title: Transcription factor hlh-2/E/Daughterless drives expression of α integrin ina-1 during DTC migration in C. elegans.
study identified the integrin-binding cytolinker plakin (VAB-10A) and integrin (INA-1/PAT-3) as key basement membrane (BM)-BM linkage regulators
Title: B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes.
We propose that CPNA-1 acts as a linker between an integrin-associated protein, PAT-6, and membrane-distal components of integrin adhesion complexes in the muscle of C. elegans.
Title: CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.
identify an essential role of the nonreceptor tyrosine kinase SRC-1 in INA-1-mediated cell corpse removal
Title: Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling.
Results reveal a role for integrin Ina-1 in regulating the plasma membrane targeting and netrin-dependent orientation of a specialized invasive membrane domain.
Title: Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.
INA-1 plays an important role in defining the distinct migratory behavior of Q neuroblasts in C. elegans.
Title: Molecular signatures of cell migration in C. elegans Q neuroblasts.
ten-1 is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1
Title: Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.
Double-mutant analysis between mnp-1, ina-1, and vab-1 mutations; as well as tissue specific rescue experiments; indicated that each of these function predominantly independent of each other and from different cell types to affect muscle cell migration.
Title: Muscle cell migrations of C. elegans are mediated by the alpha-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1.
down-regulation of ina-1 is necessary for distal tip cell migration cessation and the up-regulation of pat-2 is required for directionality
Title: Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54G8.3 (e-PCR)
- UniSTS:311797

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
part_of integrin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Integrin alpha ina-1

NP_499032.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9168073..9172802 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066631.8 → NP_499032.1 Integrin alpha ina-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499032.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03600

Conserved Domains (2) summary

smart00191
Location:317 → 362

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:495 → 1005

Integrin_alpha2; Integrin alpha