ZK512.2 ATP-dependent RNA helicase;putative ATP-dependent RNA helicase DDX55 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ZK512.2
Official Full Name: ATP-dependent RNA helicase;putative ATP-dependent RNA helicase DDX55 homolog
Primary source: WormBase:WBGene00013983
Locus tag: CELE_ZK512.2
See related: AllianceGenome:WB:WBGene00013983
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be located in P granule. Predicted to be active in nucleolus. Is expressed in several structures, including body wall musculature; intestine; non-striated muscle; pharynx; and tail. Orthologous to human DDX55 (DEAD-box helicase 55). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ZK512.2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (9141749..9144794, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK512.2 (e-PCR)
- UniSTS:308275

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase;putative ATP-dependent RNA helicase DDX55 homolog

NP_001254980.1

Confirmed by transcript evidence

NP_001254981.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9141749..9144794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268051.2 → NP_001254980.1 putative ATP-dependent RNA helicase DDX55 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254980.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34640

Conserved Domains (4) summary

smart00487
Location:24 → 220

DEXDc; DEAD-like helicases superfamily

cd00079
Location:232 → 362

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:17 → 219

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam13959
Location:398 → 457

DUF4217; Domain of unknown function (DUF4217)
NM_001268052.3 → NP_001254981.1 ATP-dependent RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254981.1

Status: REVIEWED

UniProtKB/TrEMBL

H2FLF4

Conserved Domains (4) summary

COG0513
Location:7 → 342

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00079
Location:166 → 296

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam13959
Location:332 → 391

DUF4217; Domain of unknown function (DUF4217)

cl21455
Location:1 → 153

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases