mrpl-44 Large ribosomal subunit protein mL44 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mrpl-44
Official Full Name: Large ribosomal subunit protein mL44
Primary source: WormBase:WBGene00008514
Locus tag: CELE_F02A9.4
See related: AllianceGenome:WB:WBGene00008514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ribonuclease III activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in mitochondrion and ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in nucleus. Is expressed in metacorpus and terminal bulb. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mrpl-44 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (9084310..9089375, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F02A9.4 (e-PCR)
- UniSTS:309552

F02A9.5 (e-PCR)
- UniSTS:321335

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ribonuclease III activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial translational elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of mitochondrial large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Large ribosomal subunit protein mL44

NP_499012.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9084310..9089375 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066611.6 → NP_499012.2 Large ribosomal subunit protein mL44 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499012.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34384

Conserved Domains (1) summary

cd19874
Location:209 → 293

DSRM_MRPL44; double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins