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F44E2.6 Peptide-methionine (R)-S-oxide reductase;putative methionine-R-sulfoxide reductase B [ Caenorhabditis elegans ]

Gene ID: 176244, updated on 4-Jan-2025

Summary

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Official Symbol
F44E2.6
Official Full Name
Peptide-methionine (R)-S-oxide reductase;putative methionine-R-sulfoxide reductase B
Primary source
WormBase:WBGene00018419
Locus tag
CELE_F44E2.6
See related
AllianceGenome:WB:WBGene00018419
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptide-methionine (R)-S-oxide reductase activity. Predicted to be involved in protein repair and response to oxidative stress. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to several human genes including MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F44E2.6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (8844494..8845214, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Malectin domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Putative zinc finger protein F44E2.7 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein repair IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptide-methionine (R)-S-oxide reductase;putative methionine-R-sulfoxide reductase B
NP_001040853.1
  • Confirmed by transcript evidence
NP_001360042.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8844494..8845214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372638.3 → NP_001360042.1  putative methionine-R-sulfoxide reductase B [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34436
    Conserved Domains (1) summary
    pfam01641
    Location:29 → 150
    SelR; SelR domain

  2. NM_001047388.3 → NP_001040853.1  Peptide-methionine (R)-S-oxide reductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040853.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1W0S5
    Conserved Domains (1) summary
    cl15841
    Location:10 → 145
    SelR; SelR domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34436.1

Gene LinkOut

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