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tomm-70 Mitochondrial import receptor subunit tomm-70 [ Caenorhabditis elegans ]

Gene ID: 176228, updated on 9-Dec-2024

Summary

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Official Symbol
tomm-70
Official Full Name
Mitochondrial import receptor subunit tomm-70
Primary source
WormBase:WBGene00022722
Locus tag
CELE_ZK370.8
See related
AllianceGenome:WB:WBGene00022722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in several processes, including positive regulation of interferon-beta production; protein targeting to mitochondrion; and regulation of defense response. Located in mitochondrion. Is expressed in muscle cell and tail. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tomm-70 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (8752095..8754750, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene UDP-galactose translocator 1 Neighboring gene Dwarfin sma-2;MH2 domain-containing protein Neighboring gene ncRNA Neighboring gene 5'-AMP-activated protein kinase catalytic subunit alpha-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chaperone-interacting TPR proteins in Caenorhabditis elegans. Haslbeck V, et al. J Mol Biol, 2013 Aug 23. PMID 23727266
  2. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. Gaiser AM, et al. J Mol Biol, 2009 Aug 21. PMID 19559711
  3. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
  4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of defense response to virus by host ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial import receptor subunit tomm-70
NP_498932.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8752095..8754750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066531.7 → NP_498932.3  Mitochondrial import receptor subunit tomm-70 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498932.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02335
    Conserved Domains (2) summary
    sd00006
    Location:45 → 72
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:45 → 116
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version

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