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hadb-1 putative 3-ketoacyl-CoA thiolase [ Caenorhabditis elegans ]

Gene ID: 176216, updated on 2-Nov-2024

Summary

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Official Symbol
hadb-1
Official Full Name
putative 3-ketoacyl-CoA thiolase
Primary source
WormBase:WBGene00015125
Locus tag
CELE_B0303.3
See related
AllianceGenome:WB:WBGene00015125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and tail. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hadb-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (8686359..8688166, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene P granule abnormality protein 2 Neighboring gene pseudo Neighboring gene Protein flightless-1 homolog Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene Nicotinamide N-methyltransferase Neighboring gene Uncharacterized protein Neighboring gene SH3 domain-containing protein Neighboring gene Skn-1 dependent zygotic transcript 1 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. Waaijers S, et al. BMC Biol, 2016 Aug 9. PMID 27506200, Free PMC Article
  2. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
  3. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article
  4. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
  5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA C-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative 3-ketoacyl-CoA thiolase
NP_498915.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8686359..8688166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066514.8 → NP_498915.1  putative 3-ketoacyl-CoA thiolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498915.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34255
    Conserved Domains (2) summary
    cd00751
    Location:27 → 445
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    TIGR01930
    Location:29 → 444
    AcCoA-C-Actrans; acetyl-CoA acetyltransferases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34255.1

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