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ess-2 Splicing factor ESS-2 [ Caenorhabditis elegans ]

Gene ID: 176200, updated on 9-Dec-2024

Summary

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Official Symbol
ess-2
Official Full Name
Splicing factor ESS-2
Primary source
WormBase:WBGene00018371
Locus tag
CELE_F42H10.7
See related
AllianceGenome:WB:WBGene00018371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Located in nucleus. Is expressed in several structures, including body wall musculature and pharynx. Used to study DiGeorge syndrome and velocardiofacial syndrome. Orthologous to human ESS2 (ess-2 splicing factor homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ess-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (8488339..8490352, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene HAT C-terminal dimerization domain-containing protein;Zinc finger BED domain-containing protein 39 Neighboring gene Putative esterase F42H10.6 Neighboring gene ncRNA Neighboring gene LIM and SH3 domain protein F42H10.3 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans. Noma K, et al. Genetics, 2014 Nov. PMID 25194163, Free PMC Article
  2. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. Szewczyk NJ, et al. J Exp Biol, 2006 Oct. PMID 17023606
  3. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Fridolfsson HN, et al. Dev Biol, 2010 Feb 15. PMID 20005871, Free PMC Article
  4. Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline. Walhout AJ, et al. Curr Biol, 2002 Nov 19. PMID 12445390
  5. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function in ess-2 suppresses rpm-1 only in the presence of a dlk-1 splice acceptor mutation.
    Title: Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Splicing factor ESS-2
NP_001022580.1
  • Partially confirmed by transcript evidence
NP_001022581.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8488339..8490352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027410.5 → NP_001022581.1  Splicing factor ESS-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022581.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34420, Q6AHR6
    Conserved Domains (1) summary
    pfam09751
    Location:39 → 437
    Es2; Nuclear protein Es2

  2. NM_001027409.6 → NP_001022580.1  Splicing factor ESS-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34420
    Conserved Domains (1) summary
    pfam09751
    Location:39 → 435
    Es2; Nuclear protein Es2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34420.2

Gene LinkOut

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