C14B9.2 putative protein disulfide-isomerase A4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C14B9.2
Official Full Name: putative protein disulfide-isomerase A4
Primary source: WormBase:WBGene00015752
Locus tag: CELE_C14B9.2
See related: AllianceGenome:WB:WBGene00015752
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein disulfide isomerase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in cell surface and endoplasmic reticulum. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See C14B9.2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (8133665..8136649)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C14B9.2 (e-PCR)
- UniSTS:308550

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	HEP more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative protein disulfide-isomerase A4

NP_498775.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8133665..8136649

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066374.10 → NP_498775.2 putative protein disulfide-isomerase A4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498775.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34329

Conserved Domains (5) summary

cd02995
Location:500 → 604

PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...

cd03073
Location:366 → 476

PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...

TIGR01126
Location:152 → 253

pdi_dom; protein disulfide-isomerase domain

TIGR01130
Location:147 → 616

ER_PDI_fam; protein disulfide isomerase, eukaryotic

cl00388
Location:256 → 361

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold