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npr-17 putative G-protein coupled receptor C06G4.5 [ Caenorhabditis elegans ]

Gene ID: 176124, updated on 4-Jan-2025

Summary

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Official Symbol
npr-17
Official Full Name
putative G-protein coupled receptor C06G4.5
Primary source
WormBase:WBGene00015559
Locus tag
CELE_C06G4.5
See related
AllianceGenome:WB:WBGene00015559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in ganglia and head neurons. Orthologous to human SSTR4 (somatostatin receptor 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See npr-17 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (7990715..7996453, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Calpain clp-1 Neighboring gene KH domain-containing protein C06G4.1 Neighboring gene Uncharacterized protein Neighboring gene Cyclin-T1.1 Neighboring gene Cyclin-T1.2 Neighboring gene Lipid droplet-regulating VLDL assembly factor AUP1 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders. Katner SN, et al. Behav Brain Res, 2019 Jun 3. PMID 30802531, Free PMC Article
  2. Food preference-based screening method for identification of effectors of substance use disorders using Caenorhabditis elegans. Kim AT, et al. Life Sci, 2024 May 15. PMID 38514005
  3. Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17. Ide S, et al. Front Pharmacol, 2021. PMID 35046825, Free PMC Article
  4. An opioid-like system regulating feeding behavior in C. elegans. Cheong MC, et al. Elife, 2015 Apr 21. PMID 25898004, Free PMC Article
  5. The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission. Harris G, et al. J Neurosci, 2010 Jun 9. PMID 20534837, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans has an endogenous opioid system that acts through NPR-17.
    Title: An opioid-like system regulating feeding behavior in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative G-protein coupled receptor C06G4.5
NP_498743.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7990715..7996453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066342.5 → NP_498743.2  putative G-protein coupled receptor C06G4.5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498743.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34311
    Conserved Domains (2) summary
    pfam00001
    Location:71 → 339
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:61 → 191
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34311.3

Gene LinkOut

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