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ran-2 Ran GTPase-activating protein 2 [ Caenorhabditis elegans ]

Gene ID: 176115, updated on 4-Jan-2025

Summary

Official Symbol
ran-2
Official Full Name
Ran GTPase-activating protein 2
Primary source
WormBase:WBGene00004303
Locus tag
CELE_C29E4.3
See related
AllianceGenome:WB:WBGene00004303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in intestinal cell. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See ran-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (7933535..7937708)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Nuclear pore complex protein 15 Neighboring gene ncRNA Neighboring gene Putative galactocerebrosidase Neighboring gene Protein FMC1 homolog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear export IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Ran GTPase-activating protein 2
NP_741232.1
  • Confirmed by transcript evidence
NP_741233.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7933535..7937708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171884.5NP_741233.2  Ran GTPase-activating protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741233.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34342, Q8MYR0, Q8TA79
    Conserved Domains (2) summary
    cd00116
    Location:49370
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:478508
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_171198.8NP_741232.1  Ran GTPase-activating protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741232.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34342
    Conserved Domains (2) summary
    cd00116
    Location:12333
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:441471
    LRR_RI; leucine-rich repeat [structural motif]