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tomm-7 Mitochondrial import receptor subunit TOM7 homolog [ Caenorhabditis elegans ]

Gene ID: 176101, updated on 4-Jan-2025

Summary

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Official Symbol
tomm-7
Official Full Name
Mitochondrial import receptor subunit TOM7 homolog
Primary source
WormBase:WBGene00022783
Locus tag
CELE_ZK652.2
See related
AllianceGenome:WB:WBGene00022783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in mitochondrion organization. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Is expressed in intestine and pharynx. Orthologous to human TOMM7 (translocase of outer mitochondrial membrane 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tomm-7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (7859613..7860159)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Neighboring gene Ubiquitin-fold modifier 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Copper transport protein ATOX1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism. Wu S, et al. Exp Neurol, 2018 Nov. PMID 30076829, Free PMC Article
  2. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. Curran SP, et al. J Biol Chem, 2004 Dec 24. PMID 15485840
  3. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
  4. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial outer membrane translocase complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial import receptor subunit TOM7 homolog
NP_498706.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7859613..7860159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066305.6 → NP_498706.1  Mitochondrial import receptor subunit TOM7 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498706.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34660
    Conserved Domains (1) summary
    pfam08038
    Location:8 → 44
    Tom7; TOM7 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34660.1

Gene LinkOut

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