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mfsd-6 Major facilitator superfamily associated domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 176073, updated on 9-Dec-2024

Summary

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Official Symbol
mfsd-6
Official Full Name
Major facilitator superfamily associated domain-containing protein
Primary source
WormBase:WBGene00020051
Locus tag
CELE_R13A5.9
See related
AllianceGenome:WB:WBGene00020051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Acts upstream of or within with a positive effect on synaptic vesicle exocytosis. Located in synaptic vesicle. Is expressed in intestine and nervous system. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mfsd-6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (7575284..7579411, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Pescadillo homolog Neighboring gene CMP/dCMP-type deaminase domain-containing protein Neighboring gene Polycystin cation channel PKD1/PKD2 domain-containing protein Neighboring gene Serpentine receptor class gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans R13A5.9 gene plays a role in synaptic vesicle exocytosis. Ogurusu T, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26079877
  2. Gene Function Prediction Based on Developmental Transcriptomes of the Two Sexes in C. elegans. Kim B, et al. Cell Rep, 2016 Oct 11. PMID 27732864, Free PMC Article
  3. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article
  4. Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans. McCulloch KA, et al. G3 (Bethesda), 2017 Jul 5. PMID 28468816, Free PMC Article
  5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Major facilitator superfamily associated domain-containing protein
NP_498662.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7575284..7579411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066261.6 → NP_498662.1  Major facilitator superfamily associated domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Y88
    Conserved Domains (1) summary
    cd17335
    Location:23 → 560
    MFS_MFSD6; Major facilitator superfamily domain-containing protein 6
Nucleotide Protein
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