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psd-1 Phosphatidylserine decarboxylase beta chain [ Caenorhabditis elegans ]

Gene ID: 176027, updated on 4-Jan-2025

Summary

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Official Symbol
psd-1
Official Full Name
Phosphatidylserine decarboxylase beta chain
Primary source
WormBase:WBGene00015159
Locus tag
CELE_B0361.5
See related
AllianceGenome:WB:WBGene00015159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in lipid droplet formation and phosphatidylethanolamine biosynthetic process. Predicted to be located in lipid droplet. Predicted to be active in mitochondrion. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See psd-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (7268416..7275396, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Major sperm protein Neighboring gene Peptidase metallopeptidase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Putative methyltransferase B0361.6 Neighboring gene Putative transporter B0361.11 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease. Wang S, et al. PLoS One, 2016. PMID 27736935, Free PMC Article
  2. Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease. Wang S, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25201965, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid droplet formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Phosphatidylserine decarboxylase beta chain
NP_001021127.1
  • Confirmed by transcript evidence
NP_001021128.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7268416..7275396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025957.6 → NP_001021128.1  Phosphatidylserine decarboxylase beta chain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021128.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10949, Q6AHR5
    Conserved Domains (1) summary
    cl03656
    Location:142 → 372
    PS_Dcarbxylase; Phosphatidylserine decarboxylase

  2. NM_001025956.6 → NP_001021127.1  Phosphatidylserine decarboxylase beta chain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021127.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10949
    Conserved Domains (1) summary
    cl03656
    Location:113 → 343
    PS_Dcarbxylase; Phosphatidylserine decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10949.2

Gene LinkOut

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