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prk-1 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

Gene ID: 175980, updated on 4-Jan-2025

Summary

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Official Symbol
prk-1
Official Full Name
non-specific serine/threonine protein kinase
Primary source
WormBase:WBGene00004182
Locus tag
CELE_C06E8.3
See related
AllianceGenome:WB:WBGene00004182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in negative regulation of apoptotic process and regulation of mitotic cell cycle. Predicted to be active in cytoplasm. Is expressed in intestine and nervous system. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See prk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (6990168..7002310)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Homeobox protein ceh-20 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lipid-binding serum glycoprotein C-terminal domain-containing protein Neighboring gene Gamma-aminobutyric acid receptor subunit beta Neighboring gene ncRNA Neighboring gene Cuticle collagen 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rte-1, a retrotransposon-like element in Caenorhabditis elegans. Youngman S, et al. FEBS Lett, 1996 Feb 12. PMID 8603714
  2. PIM-Related Kinases Selectively Regulate Olfactory Sensations in Caenorhabditis elegans. Kalichamy KS, et al. eNeuro, 2019 Jul/Aug. PMID 31387876, Free PMC Article
  3. Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank. Zwaal RR, et al. Proc Natl Acad Sci U S A, 1993 Aug 15. PMID 8395047, Free PMC Article
  4. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Trachtulec Z, et al. Mamm Genome, 2001 Mar. PMID 11252172
  5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
non-specific serine/threonine protein kinase
NP_001263706.1
  • Confirmed by transcript evidence
NP_001364690.1
  • Confirmed by transcript evidence
NP_001364691.1
  • Confirmed by transcript evidence
NP_498528.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6990168..7002310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276777.4 → NP_001263706.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263706.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ESD7
    Conserved Domains (1) summary
    cd14005
    Location:56 → 309
    STKc_PIM; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase

  2. NM_001377564.1 → NP_001364690.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYI1
    Conserved Domains (1) summary
    cd14005
    Location:33 → 286
    STKc_PIM; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase

  3. NM_001377565.2 → NP_001364691.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3F1
    Conserved Domains (1) summary
    cd14005
    Location:33 → 286
    STKc_PIM; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase

  4. NM_066127.5 → NP_498528.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498528.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYI2
    Conserved Domains (1) summary
    cl21453
    Location:33 → 199
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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