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rbf-1 Rabphilin-1 [ Caenorhabditis elegans ]

Gene ID: 175943, updated on 4-Jan-2025

Summary

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Official Symbol
rbf-1
Official Full Name
Rabphilin-1
Primary source
WormBase:WBGene00004316
Locus tag
CELE_F37A4.7
See related
AllianceGenome:WB:WBGene00004316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in dense core granule exocytosis and positive regulation of locomotion. Located in synaptic vesicle. Is expressed in dorsal nerve cord; nerve ring; neurons; and ventral nerve cord. Orthologous to several human genes including RPH3A (rabphilin 3A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rbf-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
22
Sequence:
Chromosome: III; NC_003281.10 (6675760..6703998)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chromatin-remodeling complex ATPase chain isw-1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3. Staunton J, et al. J Neurosci, 2001 Dec 1. PMID 11717359, Free PMC Article
  2. RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans. Feng W, et al. Sci China Life Sci, 2012 Mar. PMID 22527519
  3. Sequenced Breakpoints of Crossover Suppressor/Inversion qC1. Edgley ML, et al. MicroPubl Biol, 2021. PMID 34746683, Free PMC Article
  4. HID-1, a new component of the peptidergic signaling pathway. Mesa R, et al. Genetics, 2011 Feb. PMID 21115972, Free PMC Article
  5. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Wang Y, et al. Nature, 1997 Aug 7. PMID 9252191

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dense core granule exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rabphilin-1
NP_001022566.1
  • Confirmed by transcript evidence
NP_001022567.1
  • Confirmed by transcript evidence
NP_001367825.1
  • Confirmed by transcript evidence
NP_001379930.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6675760..6703998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379772.1 → NP_001367825.1  Rabphilin-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
    Conserved Domains (3) summary
    cd04035
    Location:845 → 967
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:987 → 1119
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    pfam02318
    Location:220 → 342
    FYVE_2; FYVE-type zinc finger

  2. NM_001392126.1 → NP_001379930.1  Rabphilin-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
    Conserved Domains (3) summary
    cd04035
    Location:675 → 797
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:817 → 949
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    pfam02318
    Location:50 → 172
    FYVE_2; FYVE-type zinc finger

  3. NM_001027396.5 → NP_001022567.1  Rabphilin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022567.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
    Conserved Domains (3) summary
    cd04035
    Location:684 → 806
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:826 → 958
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    pfam02318
    Location:60 → 181
    FYVE_2; FYVE-type zinc finger

  4. NM_001027395.5 → NP_001022566.1  Rabphilin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022566.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41885, Q8MQ57, Q8WT49, Q8WT50, Q962V6
    Conserved Domains (3) summary
    cd04035
    Location:750 → 872
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:892 → 1024
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    pfam02318
    Location:126 → 247
    FYVE_2; FYVE-type zinc finger
Nucleotide Protein
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