smrc-1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: smrc-1
Official Full Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog
Primary source: WormBase:WBGene00015806
Locus tag: CELE_C16A3.1
See related: AllianceGenome:WB:WBGene00015806
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP-dependent DNA/DNA annealing activity. Predicted to be involved in DNA repair; regulation of transcription by RNA polymerase II; and replication fork processing. Predicted to be located in nucleus. Predicted to be active in nuclear replication fork. Is expressed in germ line and in male. Used to study Schimke immuno-osseous dysplasia. Human ortholog(s) of this gene implicated in Schimke immuno-osseous dysplasia. Orthologous to human SMARCAL1 (SNF2 related chromatin remodeling annealing helicase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See smrc-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (6390944..6393844)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results find that SMRC-1 protects cells from DNA replication stress and promotes the accumulation of nuclear MET-2. Moreover, SMRC-1 affects MET-2 germline activity (as measured by histone modification state) in populations grown for multiple generations at stressful culture temperatures. Genetic analysis indicates that MET-2 and SMRC-1 participate in a common mechanism to limit DNA damage in the germ line.
Title: A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C16A3.1 (e-PCR)
- UniSTS:308568

C16A3.2 (e-PCR)
- UniSTS:315522

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA/DNA annealing activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog

NP_498400.1

Confirmed by transcript evidence

NP_498401.2

Confirmed by transcript evidence

NP_741192.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6390944..6393844

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066000.5 → NP_498401.2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498401.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MNV7

Conserved Domains (4) summary

COG0553
Location:132 → 625

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00046
Location:214 → 345

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:470 → 586

Helicase_C; Helicase conserved C-terminal domain

pfam07443
Location:114 → 164

HARP; HepA-related protein (HARP)
NM_171165.5 → NP_741192.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741192.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MNV7, Q95ZY8, Q95ZY9

Conserved Domains (4) summary

COG0553
Location:136 → 629

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00046
Location:218 → 349

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:474 → 590

Helicase_C; Helicase conserved C-terminal domain

pfam07443
Location:118 → 168

HARP; HepA-related protein (HARP)
NM_065999.6 → NP_498400.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498400.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MNV7

Conserved Domains (4) summary

COG0553
Location:133 → 626

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00046
Location:215 → 346

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:471 → 587

Helicase_C; Helicase conserved C-terminal domain

pfam07443
Location:115 → 165

HARP; HepA-related protein (HARP)