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npp-10 Nuclear pore complex protein Nup98 [ Caenorhabditis elegans ]

Gene ID: 175852, updated on 4-Jan-2025

Summary

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Official Symbol
npp-10
Official Full Name
Nuclear pore complex protein Nup98
Primary source
WormBase:WBGene00003796
Locus tag
CELE_ZK328.5
See related
AllianceGenome:WB:WBGene00003796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA binding activity. Involved in several processes, including mitotic chromosome centromere condensation; nuclear pore localization; and protein localization to organelle. Located in P granule; kinetochore; and nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See npp-10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (6013447..6019562, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein 26;SH3 domain-containing protein Neighboring gene Germ cell nuclear acidic-1 protein Neighboring gene Tr-type G domain-containing protein Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase cyk-3 Neighboring gene Putative T-box protein 7 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improved CRISPR/Cas9 knock-in efficiency via the self-excising cassette (SEC) selection method in C. elegans. Huang G, et al. MicroPubl Biol, 2021. PMID 34549176, Free PMC Article
  2. The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules. Voronina E, et al. Development, 2010 May. PMID 20335358, Free PMC Article
  3. The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans. Miwa T, et al. Genes Cells, 2022 Oct. PMID 35950937
  4. Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity. Schmidt HB, et al. Elife, 2015 Jan 6. PMID 25562883, Free PMC Article
  5. Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz C, et al. EMBO J, 2005 Oct 19. PMID 16193066, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in P granule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic chromosome centromere condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear pore localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere tethering at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear pore cytoplasmic filaments IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear pore complex protein Nup98
NP_001254934.1
  • Confirmed by transcript evidence
NP_001367842.1
  • Confirmed by transcript evidence
NP_498310.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6013447..6019562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379737.1 → NP_001367842.1  Nuclear pore complex protein Nup98 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D1MN48, G5EEH9, H2L014
    Conserved Domains (3) summary
    pfam04096
    Location:777 → 919
    Nucleoporin2; Nucleoporin autopeptidase
    pfam12110
    Location:1259 → 1512
    Nup96; Nuclear protein 96
    pfam13634
    Location:237 → 334
    Nucleoporin_FG; Nucleoporin FG repeat region

  2. NM_065909.6 → NP_498310.3  Nuclear pore complex protein Nup98 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498310.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEH9
    Conserved Domains (2) summary
    pfam04096
    Location:779 → 919
    Nucleoporin2; Nucleoporin autopeptidase
    pfam13634
    Location:214 → 322
    Nucleoporin_FG; Nucleoporin FG repeat region

  3. NM_001268005.2 → NP_001254934.1  Nuclear pore complex protein Nup98 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254934.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEH9
    Conserved Domains (2) summary
    pfam04096
    Location:781 → 921
    Nucleoporin2; Nucleoporin autopeptidase
    pfam13634
    Location:216 → 324
    Nucleoporin_FG; Nucleoporin FG repeat region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EEH9.1

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