F25B5.5 CDK5RAP1-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F25B5.5
Official Full Name: CDK5RAP1-like protein
Primary source: WormBase:WBGene00017776
Locus tag: CELE_F25B5.5
See related: AllianceGenome:WB:WBGene00017776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable N6-isopentenyladenosine methylthiotransferase activity. Predicted to be involved in mitochondrial tRNA modification and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be active in cytosol and mitochondrion. Orthologous to human CDK5RAP1 (CDK5 regulatory subunit associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F25B5.5 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (5943833..5946124, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25B5.6 (e-PCR)
- UniSTS:306201

F25B5.5 (e-PCR)
- UniSTS:309927

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables N6-isopentenyladenosine methylthiotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylthiotransferase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial tRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA modification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CDK5RAP1-like protein

NP_498290.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5943833..5946124 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065889.8 → NP_498290.1 CDK5RAP1-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498290.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09316

Conserved Domains (3) summary

PRK14329
Location:62 → 544

PRK14329; (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional

pfam00919
Location:80 → 178

UPF0004; Uncharacterized protein family UPF0004

pfam01938
Location:478 → 542

TRAM; TRAM domain