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zmp-1 Matrix metalloproteinase-A [ Caenorhabditis elegans ]

Gene ID: 175839, updated on 23-Jan-2025

Summary

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Official Symbol
zmp-1
Official Full Name
Matrix metalloproteinase-A
Primary source
WormBase:WBGene00006987
Locus tag
CELE_EGAP1.3
See related
AllianceGenome:WB:WBGene00006987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Is expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Orthologous to human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See zmp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (5926895..5932953, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Tryptophan 2,3-dioxygenase Neighboring gene Uncharacterized protein Neighboring gene putative dynactin subunit 2 Neighboring gene BCL7-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene Ubiquitin-related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of matrix metalloproteinase ZMP-2 in pathogen resistance and development in Caenorhabditis elegans. Altincicek B, et al. Dev Comp Immunol, 2010 Nov. PMID 20600277
  2. Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain. Naegeli KM, et al. Dev Cell, 2017 Nov 20. PMID 29161591, Free PMC Article
  3. Anchors away! Fos fosters anchor-cell invasion. Montell DJ. Cell, 2005 Jun 17. PMID 15960969
  4. The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis. Kato M, et al. Development, 2009 Dec. PMID 19906858, Free PMC Article
  5. Invadosomes in their natural habitat. Génot E, et al. Eur J Cell Biol, 2014 Oct. PMID 25457677, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in basement membrane disassembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Matrix metalloproteinase-A
NP_741156.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5926895..5932953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171138.3 → NP_741156.1  Matrix metalloproteinase-A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741156.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGM1
    Conserved Domains (3) summary
    cd00094
    Location:308 → 483
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:102 → 257
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:28 → 75
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGM1.1

Gene LinkOut

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