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erd-2.2 ER lumen protein-retaining receptor erd-2.2 [ Caenorhabditis elegans ]

Gene ID: 175833, updated on 2-Nov-2024

Summary

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Official Symbol
erd-2.2
Official Full Name
ER lumen protein-retaining receptor erd-2.2
Primary source
WormBase:WBGene00016195
Locus tag
CELE_C28H8.4
See related
AllianceGenome:WB:WBGene00016195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ER retention sequence binding activity. Predicted to be involved in protein retention in ER lumen; protein transport; and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See erd-2.2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (5907049..5908457)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Paxillin homolog 1 Neighboring gene Zinc finger protein dpff-1 Neighboring gene putative helicase C28H8.3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allele-specific suppression in Caenorhabditis elegans reveals details of EMS mutagenesis and a possible moonlighting interaction between the vesicular acetylcholine transporter and ERD2 receptors. Mathews EA, et al. Genetics, 2021 Aug 9. PMID 33914877, Free PMC Article
  2. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. Gaeta AL, et al. PLoS Genet, 2022 Aug. PMID 35984862, Free PMC Article
  3. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ER retention sequence binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein retention in ER lumen IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER lumen protein-retaining receptor erd-2.2
NP_498282.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5907049..5908457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065881.5 → NP_498282.1  ER lumen protein-retaining receptor erd-2.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498282.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09473
    Conserved Domains (1) summary
    pfam00810
    Location:28 → 169
    ER_lumen_recept; ER lumen protein retaining receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09473.1

Gene LinkOut

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