U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pxl-1 Paxillin homolog 1 [ Caenorhabditis elegans ]

Gene ID: 175831, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
pxl-1
Official Full Name
Paxillin homolog 1
Primary source
WormBase:WBGene00016197
Locus tag
CELE_C28H8.6
See related
AllianceGenome:WB:WBGene00016197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables vinculin binding activity. Involved in muscle structure development; nematode larval development; and nematode pharyngeal pumping. Located in adherens junction; contractile muscle fiber; and podosome. Is expressed in body wall musculature and pharynx. Orthologous to several human genes including LPXN (leupaxin) and PXN (paxillin). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pxl-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (5889721..5896013, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Zinc finger protein dpff-1 Neighboring gene ER lumen protein-retaining receptor erd-2.2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. Qadota H, et al. Mol Biol Cell, 2007 Nov. PMID 17761533, Free PMC Article
  2. The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability. Warner A, et al. Mol Biol Cell, 2011 Jul 15. PMID 21633109, Free PMC Article
  3. Molecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscle. Qadota H, et al. J Biomed Biotechnol, 2010. PMID 20414365, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a loss-of-function allele of pxl-1 shows that loss of paxillin leads to early larval arrested animals with paralyzed pharyngeal muscles and eventual lethality
    Title: The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables vinculin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle structure development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in podosome IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Paxillin homolog 1
NP_001021185.2
  • Confirmed by transcript evidence
NP_001021186.1
  • Confirmed by transcript evidence
NP_001122677.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5889721..5896013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026015.3 → NP_001021186.1  Paxillin homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021186.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09476
    Conserved Domains (2) summary
    pfam00412
    Location:148 → 203
    LIM; LIM domain
    cl02475
    Location:87 → 141
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001129205.4 → NP_001122677.1  Paxillin homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122677.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09476
    Conserved Domains (4) summary
    cd09338
    Location:233 → 285
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09339
    Location:292 → 343
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    pfam00412
    Location:174 → 229
    LIM; LIM domain
    cl02475
    Location:113 → 167
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001026014.5 → NP_001021185.2  Paxillin homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021185.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7YEM2, A7YEP3, A8WEL3, Q09476, Q6AHR2
    Conserved Domains (4) summary
    cd09338
    Location:294 → 346
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09339
    Location:353 → 404
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cd09406
    Location:174 → 228
    LIM1_Leupaxin; The first LIM domain of Leupaxin
    pfam00412
    Location:235 → 290
    LIM; LIM domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09476.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools