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rabn-5 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175823, updated on 2-Nov-2024

Summary

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Official Symbol
rabn-5
Official Full Name
FYVE-type domain-containing protein
Primary source
WormBase:WBGene00017161
Locus tag
CELE_F01F1.4
See related
AllianceGenome:WB:WBGene00017161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activating protein binding activity. Involved in molting cycle. Orthologous to several human genes including RABEP1 (rabaptin, RAB GTPase binding effector protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rabn-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (5864553..5866541)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative aldehyde dehydrogenase family 7 member A1 homolog Neighboring gene Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein Neighboring gene Aspartyl aminopeptidase Neighboring gene mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Neighboring gene DUF3456 domain-containing protein Neighboring gene PAP-associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Wang Y, et al. Nature, 1997 Aug 7. PMID 9252191
  2. RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Sasidharan N, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23100538, Free PMC Article
  3. Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit. Sato M, et al. Nat Cell Biol, 2005 Jun. PMID 15895077, Free PMC Article
  4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in molting cycle, collagen and cuticulin-based cuticle IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
FYVE-type domain-containing protein
NP_498266.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5864553..5866541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065865.7 → NP_498266.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19088
    Conserved Domains (2) summary
    cd15739
    Location:338 → 410
    FYVE_RABE_unchar; FYVE domain found in uncharacterized rab GTPase-binding effector proteins from bilateria
    pfam09311
    Location:37 → 336
    Rab5-bind; Rabaptin-like protein
Nucleotide Protein
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