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lgg-3 Ubiquitin-like protein atg-12 [ Caenorhabditis elegans ]

Gene ID: 175793, updated on 9-Dec-2024

Summary

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Official Symbol
lgg-3
Official Full Name
Ubiquitin-like protein atg-12
Primary source
WormBase:WBGene00002982
Locus tag
CELE_B0336.8
See related
AllianceGenome:WB:WBGene00002982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tag activity. Predicted to contribute to Atg8-family ligase activity. Involved in cellular response to toxic substance; determination of adult lifespan; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Orthologous to human ATG12 (autophagy related 12). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lgg-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (5697494..5698013, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ARF7 effector protein C-terminal domain-containing protein Neighboring gene Transcription initiation factor IIA small chain homolog Neighboring gene THAP-type domain-containing protein Neighboring gene RGS domain-containing protein;Regulator of G-protein signaling rgs-5 Neighboring gene Protein SWAP;SURP motif domain-containing protein;Suppressor of white apricot N-terminal domain-containing protein Neighboring gene Large ribosomal subunit protein uL14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A protein conjugation system essential for autophagy. Mizushima N, et al. Nature, 1998 Sep 24. PMID 9759731
  2. Autophagy regulates ageing in C. elegans. Hars ES, et al. Autophagy, 2007 Mar-Apr. PMID 17204841
  3. HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Chen HD, et al. Autophagy, 2017 Feb. PMID 27875098, Free PMC Article
  4. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article
  5. The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery. Lin L, et al. J Cell Biol, 2013 Apr 1. PMID 23530068, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to Atg8-family ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_positive_effect plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Atg12-Atg5-Atg16 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ubiquitin-like protein atg-12
NP_498228.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5697494..5698013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065827.3 → NP_498228.1  Ubiquitin-like protein atg-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498228.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10931
    Conserved Domains (1) summary
    cl28922
    Location:28 → 118
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10931.1

Gene LinkOut

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