U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

skpt-1 F-box domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175749, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
skpt-1
Official Full Name
F-box domain-containing protein
Primary source
WormBase:WBGene00018613
Locus tag
CELE_F48E8.7
See related
AllianceGenome:WB:WBGene00018613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See skpt-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (5446511..5448395, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DM2 domain-containing protein Neighboring gene DIS3-like exonuclease 2 Neighboring gene Hsp20/alpha crystallin family protein Neighboring gene putative serine/threonine-protein phosphatase PP2A regulatory subunit

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Kim Y, et al. Mol Cell Biol, 2007 Feb. PMID 17145765, Free PMC Article
  2. Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Yamanaka A, et al. Curr Biol, 2002 Feb 19. PMID 11864566
  3. The F-box protein family. Kipreos ET, et al. Genome Biol, 2000. PMID 11178263, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
F-box domain-containing protein
NP_741136.1
  • Confirmed by transcript evidence
NP_741137.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5446511..5448395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171121.5 → NP_741136.1  F-box domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741136.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ34
    Conserved Domains (3) summary
    cd09293
    Location:147 → 370
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:150 → 180
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:89 → 127
    F-box-like

  2. NM_171865.7 → NP_741137.1  F-box domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09397
    Conserved Domains (3) summary
    cd09293
    Location:150 → 373
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:153 → 183
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:92 → 130
    F-box-like
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous