paqr-2 Adiponectin receptor protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: paqr-2
Official Full Name: Adiponectin receptor protein
Primary source: WormBase:WBGene00021313
Locus tag: CELE_Y32H12A.5
See related: AllianceGenome:WB:WBGene00021313
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable signaling receptor activity. Involved in positive regulation of fatty acid oxidation; response to cold; and tail spike morphogenesis. Located in plasma membrane. Is expressed in gonadal sheath cell; head muscle; nervous system; and seam cell. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; metabolic dysfunction-associated steatotic liver disease; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human ADIPOR1 (adiponectin receptor 1) and ADIPOR2 (adiponectin receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See paqr-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (5375699..5379929, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
Title: AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated fats.
Title: The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated fats.
We conclude that acs-13 mutations in C. elegans and ACSL1 knockdown in human cells prevent lipotoxicity by promoting increased levels of polyunsaturated fatty acid-containing phospholipids
Title: Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity.
The Caenorhabditis elegans adiponectin receptor AdipoR2 homolog PAQR-2 signaling detects temperature drop and augments the biosynthesis of two omega-6 polyunsaturated fatty acids, gamma-linolenic acid and arachidonic acid. These two polyunsaturated fatty acids in turn initiate autophagy in the epidermis, delaying an age-dependent decline in collagen contents, and extending the lifespan.
Title: Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy.
We conclude that the PAQR-2 and AdipoR2 proteins share an evolutionarily conserved function that maintains membrane fluidity in the presence of exogenous saturated fatty acids.
Title: The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids.
PAQR-2 and IGLR-2 interact on plasma membranes and thus may act together as a fluidity sensor that controls membrane lipid composition.
Title: Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition.
This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant.
Title: PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y32H12A.d (e-PCR)
- UniSTS:323618

Y32H12A.c (e-PCR)
- UniSTS:324166

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid oxidation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail spike morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Adiponectin receptor protein

NP_498148.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5375699..5379929 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065747.8 → NP_498148.2 Adiponectin receptor protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498148.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9N536

Conserved Domains (1) summary

pfam03006
Location:305 → 526

HlyIII; Haemolysin-III related