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szy-2 Protein phosphatase inhibitor 2 [ Caenorhabditis elegans ]

Gene ID: 175738, updated on 2-Nov-2024

Summary

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Official Symbol
szy-2
Official Full Name
Protein phosphatase inhibitor 2
Primary source
WormBase:WBGene00021312
Locus tag
CELE_Y32H12A.4
See related
AllianceGenome:WB:WBGene00021312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein phosphatase inhibitor activity. Involved in several processes, including centrosome cycle; chromosome separation; and regulation of centrosome duplication. Orthologous to several human genes including PPP1R2B (PPP1R2 family member B) and PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See szy-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (5368966..5371276, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Dehydrogenase/reductase SDR family member 1 Neighboring gene Adiponectin receptor protein Neighboring gene Flavodoxin-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation and functions of inhibitor-2 family of proteins. Li M, et al. Biochemistry, 2007 Mar 6. PMID 17286390
  2. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. Peel N, et al. PLoS Genet, 2017 Jan. PMID 28103229, Free PMC Article
  3. Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans. Kemp CA, et al. Genetics, 2007 May. PMID 17446307, Free PMC Article
  4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of centrosome duplication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein phosphatase inhibitor 2
NP_498147.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5368966..5371276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065746.6 → NP_498147.1  Protein phosphatase inhibitor 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498147.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N537
    Conserved Domains (1) summary
    pfam04979
    Location:52 → 169
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
Nucleotide Protein
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