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nex-1 Annexin [ Caenorhabditis elegans ]

Gene ID: 175714, updated on 2-Nov-2024

Summary

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Official Symbol
nex-1
Official Full Name
Annexin
Primary source
WormBase:WBGene00003588
Locus tag
CELE_ZC155.1
See related
AllianceGenome:WB:WBGene00003588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heparin binding activity and phospholipid binding activity. Involved in engulfment of apoptotic cell. Located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in hypodermis; pharynx; spermathecal-uterine junction; uterine toroidal epithelial cell; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nex-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (5225621..5226804)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cuticlin-like protein 19 Neighboring gene Histone H2A/H2B/H3 domain-containing protein Neighboring gene rRNA-processing protein UTP23 homolog Neighboring gene CHCH domain-containing protein;CX9C domain-containing protein Neighboring gene ATP synthase subunit beta, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ligand-binding properties of annexin from Caenorhabditis elegans (annexin XVI, Nex-1). Satoh A, et al. J Biochem, 2000 Sep. PMID 10965035
  2. Caenorhabditis elegans proteins captured by immobilized Galβ1-4Fuc disaccharide units: assignment of 3 annexins. Takeuchi T, et al. Carbohydr Res, 2011 Sep 27. PMID 21798523
  3. Identification, localization, and functional implications of an abundant nematode annexin. Creutz CE, et al. J Cell Biol, 1996 Mar. PMID 8601586, Free PMC Article
  4. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
  5. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Annexin
NP_498109.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5225621..5226804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065708.10 → NP_498109.1  Annexin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498109.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEA8
    Conserved Domains (3) summary
    smart00335
    Location:33 → 81
    ANX; Annexin repeats
    pfam00191
    Location:88 → 153
    Annexin; Annexin
    cl02574
    Location:192 → 238
    Annexin; Annexin
Nucleotide Protein
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