coq-8 Atypical kinase coq-8, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: coq-8
Official Full Name: Atypical kinase coq-8, mitochondrial
Primary source: WormBase:WBGene00000767
Locus tag: CELE_C35D10.4
See related: AllianceGenome:WB:WBGene00000767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and transferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Is expressed in coelomocyte; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9 and primary coenzyme Q10 deficiency 4. Orthologous to human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See coq-8 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (4863427..4866948)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans.
Title: Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans.
The differential expression of coq-8 gene is decribed during development.
Title: Differential expression pattern of coq-8 gene during development in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C35D10.4 (e-PCR)
- UniSTS:309257

C35D10.5 (e-PCR)
- UniSTS:320477

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Atypical kinase coq-8, mitochondrial

NP_498014.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4863427..4866948

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065613.10 → NP_498014.2 Atypical kinase coq-8, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498014.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18486

Conserved Domains (2) summary

COG0661
Location:298 → 707

AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]

cd13970
Location:394 → 648

ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3