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metl-5 rRNA N6-adenosine-methyltransferase metl-5 [ Caenorhabditis elegans ]

Gene ID: 175637, updated on 14-Nov-2024

Summary

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Official Symbol
metl-5
Official Full Name
rRNA N6-adenosine-methyltransferase metl-5
Primary source
WormBase:WBGene00008008
Locus tag
CELE_C38D4.9
See related
AllianceGenome:WB:WBGene00008008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation in response to stress and rRNA base methylation. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See metl-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (4803007..4804753)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene HTH OST-type domain-containing protein Neighboring gene Rho-GAP domain-containing protein;WW domain-containing protein tag-325 Neighboring gene Homeobox protein pal-1 Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel deletion alleles of a C. elegans gene C38D4.9, named as tm4476 and tm4561. Yoshina S, et al. MicroPubl Biol, 2017 Oct 3. PMID 32550349, Free PMC Article
  2. Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth. Rong B, et al. Cell Rep, 2020 Dec 22. PMID 33357433
  3. N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Liberman N, et al. Sci Adv, 2020 Apr. PMID 32494643, Free PMC Article
  4. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine-N6-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (adenine-N6-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA (adenine-N6-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA base methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
rRNA N6-adenosine-methyltransferase metl-5
NP_497990.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4803007..4804753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065589.7 → NP_497990.1  rRNA N6-adenosine-methyltransferase metl-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497990.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18511
    Conserved Domains (1) summary
    cl17173
    Location:4 → 213
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18511.1

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