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pan-1 P-granule-associated novel protein 1 [ Caenorhabditis elegans ]

Gene ID: 175596, updated on 9-Dec-2024

Summary

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Official Symbol
pan-1
Official Full Name
P-granule-associated novel protein 1
Primary source
WormBase:WBGene00003915
Locus tag
CELE_M88.6
See related
AllianceGenome:WB:WBGene00003915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DEAD/H-box RNA helicase binding activity. Involved in germ cell development and molting cycle. Located in P granule and plasma membrane. Is expressed in several structures, including body wall musculature; gonad; hypodermis; intestine; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pan-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
10
Sequence:
Chromosome: III; NC_003281.10 (4562738..4566283)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene K Homology domain-containing protein Neighboring gene Malonyl-CoA decarboxylase, mitochondrial Neighboring gene Isocitrate dehydrogenase [NAD] subunit, mitochondrial Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling. Xia SL, et al. Elife, 2021 May 5. PMID 33950834, Free PMC Article
  2. The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition. Gissendanner CR, et al. BMC Dev Biol, 2013 May 17. PMID 23682709, Free PMC Article
  3. PAN-1, a P-granule component important for C. elegans fertility, has dual roles in the germline and soma. Gao G, et al. Dev Biol, 2012 Apr 15. PMID 22342905
  4. Functional genomic analysis of C. elegans molting. Frand AR, et al. PLoS Biol, 2005 Oct. PMID 16122351, Free PMC Article
  5. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Hayes GD, et al. Development, 2006 Dec. PMID 17065234

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.
    Title: The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.
  2. This report demonstrated that, while loss of PAN-1 in the soma inhibits molting, PAN-1 is also a P-granule component that is essential for fertility.
    Title: PAN-1, a P-granule component important for C. elegans fertility, has dual roles in the germline and soma.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in molting cycle, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P-granule-associated novel protein 1
NP_001293622.1
  • Partially confirmed by transcript evidence
NP_497924.2
  • Confirmed by transcript evidence
NP_497925.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4562738..4566283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065524.6 → NP_497925.1  P-granule-associated novel protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497925.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21604, Q9U3A0, S6FWR2
    Conserved Domains (3) summary
    cd00116
    Location:80 → 326
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:130 → 152
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:199 → 259
    LRR_8; Leucine rich repeat

  2. NM_065523.8 → NP_497924.2  P-granule-associated novel protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497924.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3A0
    Conserved Domains (4) summary
    cd00116
    Location:11 → 125
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:12 → 35
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:34 → 83
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:11 → 78
    LRR_8; Leucine rich repeat

  3. NM_001306693.3 → NP_001293622.1  P-granule-associated novel protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293622.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3A0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U3A0.1

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