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wht-3 ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175528, updated on 2-Nov-2024

Summary

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Official Symbol
wht-3
Official Full Name
ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein
Primary source
WormBase:WBGene00007631
Locus tag
CELE_C16C10.12
See related
AllianceGenome:WB:WBGene00007631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wht-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (4147425..4151598, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hemiasterlin resistant protein 1 Neighboring gene Glyoxalase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans. Ferrier A, et al. PLoS One, 2011. PMID 22073173, Free PMC Article
  2. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
  3. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article
  4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein
NP_001309589.1
  • Confirmed by transcript evidence
NP_001309590.1
  • Confirmed by transcript evidence
NP_001309591.1
  • Confirmed by transcript evidence
NP_497825.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4147425..4151598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065424.3 → NP_497825.2  ABC transporter ATP-binding protein/permease wht-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09466
    Conserved Domains (3) summary
    cd03213
    Location:36 → 263
    ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
    TIGR00955
    Location:37 → 614
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:351 → 555
    ABC2_membrane; ABC-2 type transporter

  2. NM_001322779.3 → NP_001309589.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09466
    UniProtKB/TrEMBL
    A0A131MAX2
    Conserved Domains (1) summary
    TIGR00955
    Location:37 → 600
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

  3. NM_001322780.3 → NP_001309591.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09466
    UniProtKB/TrEMBL
    A0A131MCE2
    Conserved Domains (3) summary
    TIGR00955
    Location:1 → 528
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:265 → 469
    ABC2_membrane; ABC-2 type transporter
    cl21455
    Location:3 → 177
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001322781.3 → NP_001309590.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09466
    UniProtKB/TrEMBL
    A0A131MBH6
    Conserved Domains (1) summary
    TIGR00955
    Location:1 → 542
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
Nucleotide Protein
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