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rcq-5 ATP-dependent DNA helicase [ Caenorhabditis elegans ]

Gene ID: 175522, updated on 9-Dec-2024

Summary

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Official Symbol
rcq-5
Official Full Name
ATP-dependent DNA helicase
Primary source
WormBase:WBGene00004322
Locus tag
CELE_E03A3.2
See related
AllianceGenome:WB:WBGene00004322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Located in nucleus. Is expressed in several structures, including germ line. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rcq-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (4052254..4057976, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Putative histone H3.3-like type 3 Neighboring gene Histone H3.3-like type 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiency of Caenorhabditis elegans RecQ5 homologue reduces life span and increases sensitivity to ionizing radiation. Jeong YS, et al. DNA Repair (Amst), 2003 Dec 9. PMID 14642561
  2. Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans. Kruisselbrink E, et al. Curr Biol, 2008 Jun 24. PMID 18538569
  3. C. elegans: a model of Fanconi anemia and ICL repair. Youds JL, et al. Mutat Res, 2009 Jul 31. PMID 19059419
  4. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article
  5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent DNA helicase
NP_001309439.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4052254..4057976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322778.4 → NP_001309439.1  ATP-dependent DNA helicase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19046
    Conserved Domains (4) summary
    COG0514
    Location:182 → 617
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
    cd00079
    Location:427 → 529
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:180 → 350
    DEAD; DEAD/DEAH box helicase
    pfam16124
    Location:558 → 610
    RecQ_Zn_bind; RecQ zinc-binding
Nucleotide Protein
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