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rilp-1 RILP-like protein 1 [ Caenorhabditis elegans ]

Gene ID: 175465, updated on 9-Dec-2024

Summary

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Official Symbol
rilp-1
Official Full Name
RILP-like protein 1
Primary source
WormBase:WBGene00007860
Locus tag
CELE_C32A3.3
See related
AllianceGenome:WB:WBGene00007860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Predicted to be involved in cilium assembly. Predicted to be located in membrane. Predicted to be active in ciliary basal body and cytoplasm. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 4. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rilp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (3636144..3643669)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative potassium channel regulatory protein unc-93 Neighboring gene MADF domain-containing protein Neighboring gene Glutathione reductase, mitochondrial Neighboring gene RING-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics. Luo S, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33531362, Free PMC Article
  2. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
  3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables MAP-kinase scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RILP-like protein 1
NP_741113.3
  • Confirmed by transcript evidence
NP_741114.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3636144..3643669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171100.9 → NP_741113.3  RILP-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741113.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFB9
    Conserved Domains (5) summary
    pfam07200
    Location:165 → 290
    Mod_r; Modifier of rudimentary (Mod(r)) protein
    pfam09744
    Location:21 → 165
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11461
    Location:262 → 296
    RILP; Rab interacting lysosomal protein
    pfam14662
    Location:54 → 233
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl12013
    Location:152 → 277
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_171101.5 → NP_741114.2  RILP-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741114.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDL7
    Conserved Domains (5) summary
    pfam07200
    Location:156 → 281
    Mod_r; Modifier of rudimentary (Mod(r)) protein
    pfam09744
    Location:12 → 156
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11461
    Location:253 → 287
    RILP; Rab interacting lysosomal protein
    pfam14662
    Location:45 → 224
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl12013
    Location:143 → 268
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
Heading Accession and Version

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