nhr-6 Nuclear hormone receptor family member nhr-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-6
Official Full Name: Nuclear hormone receptor family member nhr-6
Primary source: WormBase:WBGene00003605
Locus tag: CELE_C48D5.1
See related: AllianceGenome:WB:WBGene00003605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of ovulation; and spermathecum morphogenesis. Located in nucleus. Is expressed in head ganglion; neurons; and spermatheca. Human ortholog(s) of this gene implicated in Parkinson's disease and extraskeletal myxoid chondrosarcoma. Orthologous to several human genes including NR4A2 (nuclear receptor subfamily 4 group A member 2) and NR4A3 (nuclear receptor subfamily 4 group A member 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nhr-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (3573581..3578771)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic suppression of the proliferation phenotype does not affect the differentiation phenotypes observed in nhr-6 mutants, indicating a dualistic role for nhr-6 in regulating cell proliferation and cell differentiation during spermatheca organogenesis.
Title: The C. elegans NR4A nuclear receptor gene nhr-6 promotes cell cycle progression in the spermatheca lineage.
Results show that nhr-6 and jun-1 function together to regulate development of the spermatheca and are necessary for generating an organ with the normal number of cells.
Title: C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.
Study demonstrates an in vivo requirement for NHR-6, an NR4A nuclear receptor ortholog, DNA-binding domain in a whole organism.
Title: A functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C48D5.1 (e-PCR)
- UniSTS:321292

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermathecum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-6

NP_001379487.1

Confirmed by transcript evidence

NP_497731.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3573581..3578771

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065330.8 → NP_497731.1 Nuclear hormone receptor family member nhr-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497731.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2MZB4, P41829, Q9GTI7, Q9XYB6

Conserved Domains (3) summary

cd06969
Location:266 → 340

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

smart00430
Location:405 → 560

HOLI; Ligand binding domain of hormone receptors

pfam12403
Location:165 → 261

Pax2_C; Paired-box protein 2 C terminal
NM_001393310.1 → NP_001379487.1 Nuclear hormone receptor family member nhr-6 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd06969
Location:130 → 204

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

smart00430
Location:269 → 424

HOLI; Ligand binding domain of hormone receptors