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rsu-1 Ras suppressor protein 1 [ Caenorhabditis elegans ]

Gene ID: 175451, updated on 2-Nov-2024

Summary

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Official Symbol
rsu-1
Official Full Name
Ras suppressor protein 1
Primary source
WormBase:WBGene00007924
Locus tag
CELE_C34C12.5
See related
AllianceGenome:WB:WBGene00007924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in innate immune response. Is expressed in body wall musculature; distal tip cell; epithelial cell; non-striated muscle; and ventral cord neurons. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rsu-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (3472003..3473722)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein phosphatase 6 catalytic subunit Neighboring gene SMall Integral Membrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein C34C12.6 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Preventing Illegitimate Extrasynaptic Acetylcholine Receptor Clustering Requires the RSU-1 Protein. Pierron M, et al. J Neurosci, 2016 Jun 15. PMID 27307240, Free PMC Article
  2. RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans. Jiang L, et al. iScience, 2024 Jun 21. PMID 38784006, Free PMC Article
  3. RSU-1 Maintains Integrity of Caenorhabditis elegans Vulval Muscles by Regulating α-Actinin. Wang X, et al. G3 (Bethesda), 2020 Jul 7. PMID 32461202, Free PMC Article
  4. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
  5. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ras suppressor protein 1
NP_497716.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3472003..3473722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065315.7 → NP_497716.1  Ras suppressor protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497716.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09497
    Conserved Domains (4) summary
    cd00116
    Location:53 → 164
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:36 → 57
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:57 → 95
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:57 → 114
    LRR_8; Leucine rich repeat
Nucleotide Protein
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