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F59A2.5 ACT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175444, updated on 4-Jan-2025

Summary

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Official Symbol
F59A2.5
Official Full Name
ACT domain-containing protein
Primary source
WormBase:WBGene00010305
Locus tag
CELE_F59A2.5
See related
AllianceGenome:WB:WBGene00010305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in tRNA threonylcarbamoyladenosine metabolic process. Predicted to be part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 2. Orthologous to human LAGE3 (L antigen family member 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F59A2.5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (3404863..3405469)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Pre-mRNA cleavage complex subunit Clp1 C-terminal domain-containing protein;Protein clpf-1 Neighboring gene Nuclear Pore complex Protein Neighboring gene GRIP domain-containing protein Neighboring gene ncRNA Neighboring gene protein-histidine N-methyltransferase Neighboring gene tRNA-Lys Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ACT domain-containing protein
NP_497704.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3404863..3405469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065303.4 → NP_497704.1  ACT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497704.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21019
    Conserved Domains (1) summary
    pfam09341
    Location:28 → 100
    Pcc1; Transcription factor Pcc1
Nucleotide Protein
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