hecw-1 E3 ubiquitin-protein ligase hecw-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hecw-1
Official Full Name: E3 ubiquitin-protein ligase hecw-1
Primary source: WormBase:WBGene00009738
Locus tag: CELE_F45H7.6
See related: AllianceGenome:WB:WBGene00009738
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in regulation of defense response to bacterium. Predicted to be active in cytoplasm. Is expressed in SMDVL and head neurons. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) and HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hecw-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 22

Sequence:: Chromosome: III; NC_003281.10 (3377396..3389970, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HECW-1 functions in a pair of sensory neurons to inhibit P. aeruginosa lawn avoidance behaviour through inhibition of the neuropeptide receptor NPR-1
Title: Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F45H7.6 (e-PCR)
- UniSTS:307658

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase hecw-1

NP_001317872.1

Partially confirmed by transcript evidence

NP_497697.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3377396..3389970 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065296.5 → NP_497697.2 E3 ubiquitin-protein ligase hecw-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497697.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EEJ0

Conserved Domains (3) summary

smart00456
Location:230 → 261

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:545 → 871

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:520 → 872

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001330981.3 → NP_001317872.1 E3 ubiquitin-protein ligase hecw-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSJ1, G5EEJ0, Q09291

Conserved Domains (3) summary

smart00456
Location:603 → 634

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:918 → 1244

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam07735
Location:230 → 285

FBA_2; F-box associated