klf-1 Kruppel-like factor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: klf-1
Official Full Name: Kruppel-like factor 1
Primary source: WormBase:WBGene00018990
Locus tag: CELE_F56F11.3
See related: AllianceGenome:WB:WBGene00018990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including apoptotic cell clearance; regulation of transcription by RNA polymerase II; and xenobiotic metabolic process. Acts upstream of or within determination of adult lifespan. Located in chromatin. Is expressed in hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to human KLF6 (KLF transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See klf-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (2874818..2880676)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLF-1 is a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function.
Title: KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants.
overexpression modestly extended lifespan
Title: A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction.
WWP-1 directly interacts with KLF-1 and mediates multiple monoubiquitylation of KLF-1 in vitro and in cellulo. The data support a model in which modulation of KLF-1 by WWP-1 regulates diet-restriction-induced longevity.
Title: A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56F11.3 (e-PCR)
- UniSTS:313181

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Kruppel-like factor 1

NP_497632.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

2874818..2880676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065231.5 → NP_497632.1 Kruppel-like factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497632.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TZ64

Conserved Domains (3) summary

COG5048
Location:398 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:419 → 438

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:460 → 485

zf-H2C2_2; Zinc-finger double domain