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let-805 Fibronectin type-III domain-containing protein;SHOCT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175384, updated on 4-Jan-2025

Summary

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Official Symbol
let-805
Official Full Name
Fibronectin type-III domain-containing protein;SHOCT domain-containing protein
Primary source
WormBase:WBGene00002915
Locus tag
CELE_H19M22.2
See related
AllianceGenome:WB:WBGene00002915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in hemidesmosome assembly. Located in hemidesmosome. Is expressed in hypodermis; pharynx; touch receptor neurons; and uterine seam cell. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Orthologous to human TNXB (tenascin XB). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See let-805 in Genome Data Viewer
Location:
chromosome: III
Exon count:
29
Sequence:
Chromosome: III; NC_003281.10 (2658083..2681112)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myotactin, a novel hypodermal protein involved in muscle-cell adhesion in Caenorhabditis elegans. Hresko MC, et al. J Cell Biol, 1999 Aug 9. PMID 10444073, Free PMC Article
  2. Neuron-epidermal attachment protects hyper-fragile axons from mechanical strain. Bonacossa-Pereira I, et al. Cell Rep, 2022 Mar 8. PMID 35263583
  3. A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. Zhang H, et al. Nature, 2011 Mar 3. PMID 21368832
  4. Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes. Gotenstein JR, et al. Genetics, 2018 Apr. PMID 29440357, Free PMC Article
  5. C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Ding M, et al. Development, 2003 Dec. PMID 14534136

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hemidesmosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fibronectin type-III domain-containing protein;SHOCT domain-containing protein
NP_001022640.1
  • Confirmed by transcript evidence
NP_001022641.1
  • Confirmed by transcript evidence
NP_001022643.1
  • Confirmed by transcript evidence
NP_001293642.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2658083..2681112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027470.3 → NP_001022641.1  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9UB28
    Conserved Domains (3) summary
    smart00060
    Location:2017 → 2100
    FN3; Fibronectin type 3 domain
    cd00063
    Location:1400 → 1493
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:1299 → 1386
    fn3; Fibronectin type III domain

  2. NM_001027469.3 → NP_001022640.1  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022640.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9UB29
    Conserved Domains (3) summary
    smart00060
    Location:2017 → 2100
    FN3; Fibronectin type 3 domain
    cd00063
    Location:1400 → 1493
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:1299 → 1386
    fn3; Fibronectin type III domain

  3. NM_001027472.5 → NP_001022643.1  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022643.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0C1
    Conserved Domains (3) summary
    smart00060
    Location:241 → 311
    FN3; Fibronectin type 3 domain
    cd00063
    Location:438 → 530
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:143 → 212
    fn3; Fibronectin type III domain

  4. NM_001306713.4 → NP_001293642.1  SHOCT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293642.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BKP3
Nucleotide Protein
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