smg-6 PIN domain-containing protein;PINc domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: smg-6
Official Full Name: PIN domain-containing protein;PINc domain-containing protein
Primary source: WormBase:WBGene00004884
Locus tag: CELE_Y54F10AL.2
See related: AllianceGenome:WB:WBGene00004884
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Involved in embryonic genitalia morphogenesis; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of telomerase holoenzyme complex. Is expressed in intestine. Orthologous to human SMG6 (SMG6 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See smg-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 18

Sequence:: Chromosome: III; NC_003281.10 (2473854..2486622)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SMG-6 mRNA cleavage stalls ribosomes near premature stop codons in vivo.
Title: SMG-6 mRNA cleavage stalls ribosomes near premature stop codons in vivo.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables telomerase RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryonic genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: PIN domain-containing protein;PINc domain-containing protein

NP_001367726.1

Confirmed by transcript evidence

NP_497565.1

Confirmed by transcript evidence

NP_497566.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

2473854..2486622

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065164.8 → NP_497565.1 PINc domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497565.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9BL69
NM_065165.9 → NP_497566.3 PIN domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497566.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9BL68

Conserved Domains (3) summary

cd09885
Location:1060 → 1237

PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs

pfam10373
Location:669 → 995

EST1_DNA_bind; Est1 DNA/RNA binding domain

pfam10374
Location:541 → 661

EST1; Telomerase activating protein Est1
NM_001381779.2 → NP_001367726.1 PIN domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q1T6W7

Conserved Domains (3) summary

cd09885
Location:1038 → 1215

PIN_Smg6-like; VapC-like PIN domain of human telomerase-binding protein EST1, Smg6, and other similar eukaryotic homologs

pfam10373
Location:669 → 973

EST1_DNA_bind; Est1 DNA/RNA binding domain

pfam10374
Location:540 → 661

EST1; Telomerase activating protein Est1