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strm-1 Sterol 4-C-methyltransferase strm-1 [ Caenorhabditis elegans ]

Gene ID: 175358, updated on 4-Jan-2025

Summary

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Official Symbol
strm-1
Official Full Name
Sterol 4-C-methyltransferase strm-1
Primary source
WormBase:WBGene00019198
Locus tag
CELE_H14E04.1
See related
AllianceGenome:WB:WBGene00019198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables S-adenosylmethionine-dependent methyltransferase activity. Involved in regulation of dauer larval development. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis and pharynx. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See strm-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (2402070..2406335)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cyclin-C Neighboring gene 39S ribosomal protein L30, mitochondrial Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Galectin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans. Hannich JT, et al. Dev Cell, 2009 Jun. PMID 19531354
  2. Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host. Ma G, et al. Parasit Vectors, 2019 Jan 14. PMID 30642380, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A methyltransferase, STRM-1, that modulates dafachronic acid levels and thus dauer formation, was identified.
    Title: Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol 24-C-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sterol 4-C-methyltransferase strm-1
NP_497549.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2402070..2406335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065148.7 → NP_497549.2  Sterol 4-C-methyltransferase strm-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497549.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TYP1
    Conserved Domains (1) summary
    pfam08241
    Location:100 → 197
    Methyltransf_11; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TYP1.2

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