U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

exc-6 Excretory canal abnormal protein 6 [ Caenorhabditis elegans ]

Gene ID: 175277, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
exc-6
Official Full Name
Excretory canal abnormal protein 6
Primary source
WormBase:WBGene00019030
Locus tag
CELE_F58B6.2
See related
AllianceGenome:WB:WBGene00019030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin binding activity. Involved in several processes, including epithelial cell development; regulation of microtubule polymerization; and regulation of tube size. Part of filamentous actin. Is expressed in several structures, including excretory cell; pharynx; rectal gland cell; reproductive system; and tail neurons. Orthologous to human FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See exc-6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (1103208..1111944)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans. Hegsted A, et al. Cytoskeleton (Hoboken), 2016 Dec. PMID 27770600, Free PMC Article
  2. The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons. Shaye DD, et al. Dev Cell, 2015 Mar 23. PMID 25771894
  3. The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals. Fujita M, et al. Dev Biol, 2003 Apr 15. PMID 12679103
  4. A network of conserved formins, regulated by the guanine exchange factor EXC-5 and the GTPase CDC-42, modulates tubulogenesis in vivo. Shaye DD, et al. Development, 2016 Nov 15. PMID 27697907, Free PMC Article
  5. Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans. Mi-Mi L, et al. J Cell Biol, 2012 Jul 9. PMID 22753896, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of filamentous actin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Excretory canal abnormal protein 6
NP_497334.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1103208..1111944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064933.5 → NP_497334.2  Excretory canal abnormal protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497334.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TYU9
    Conserved Domains (1) summary
    pfam02181
    Location:140 → 487
    FH2; Formin Homology 2 Domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TYU9.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools