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F23H11.4 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175253, updated on 4-Jan-2025

Summary

Official Symbol
F23H11.4
Official Full Name
Rho-GAP domain-containing protein
Primary source
WormBase:WBGene00017760
Locus tag
CELE_F23H11.4
See related
AllianceGenome:WB:WBGene00017760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Orthologous to several human genes including ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See F23H11.4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (902287..907539, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit B Neighboring gene Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Neighboring gene putative cardiolipin synthase (CMP-forming) Neighboring gene Deltamethrin resistance protein prag01 domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Rho-GAP domain-containing protein
NP_001360004.1
  • Confirmed by transcript evidence
NP_497289.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    902287..907539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064888.6NP_497289.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497289.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZV4
    Conserved Domains (2) summary
    cd04385
    Location:571759
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd17113
    Location:790882
    RA_ARAPs; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing proteins ARAP1, ARAP2, ARAP3, and similar proteins
  2. NM_001373840.2NP_001360004.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7N1