lec-6 Galectin [Caenorhabditis elegans] - Gene

Summary

Official Symbol: lec-6
Official Full Name: Galectin
Primary source: WormBase:WBGene00002269
Locus tag: CELE_Y55B1AR.1
See related: AllianceGenome:WB:WBGene00002269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable carbohydrate binding activity and galactoside binding activity. Located in cytoplasm. Is expressed in intestine and pharynx. Orthologous to several human genes including LGALS7 (galectin 7) and LGALS7B (galectin 7B). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Study concludes that the Glu67 in the oligosaccharide-binding site assists the recognition of the fucose moiety by LEC-6.
Title: Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6.
a model where LEC-6 and LEC-10 interact with glycoproteins through specific glycans to regulate their cellular fate.
Title: Caenorhabditis elegans galectins LEC-6 and LEC-10 interact with similar glycoconjugates in the intestine.
Galectins LEC-6 and LEC-1 recognize a chemically synthesized Galbeta1-4Fuc disaccharide unit.
Title: Caenorhabditis elegans galectins LEC-6 and LEC-1 recognize a chemically synthesized Galbeta1-4Fuc disaccharide unit which is present in Protostomia glycoconjugates.
N-glycans containing a Gal-Fuc disaccharide unit linked to the innermost GlcNAc residue are recognized by C. elegans galectin LEC-6
Title: Caenorhabditis elegans N-glycans containing a Gal-Fuc disaccharide unit linked to the innermost GlcNAc residue are recognized by C. elegans galectin LEC-6.
The carbohydrate specificity of the 16kDa "proto" galectin mediates binding to blood group precursor oligosaccharides and gangliosides.
Title: Novel carbohydrate specificity of the 16-kDa galectin from Caenorhabditis elegans: binding to blood group precursor oligosaccharides (type 1, type 2, Talpha, and Tbeta) and gangliosides.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables galactoside binding	IBA Inferred from Biological aspect of Ancestor more info