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mat-3 Cell division cycle protein 23 homolog [ Caenorhabditis elegans ]

Gene ID: 175205, updated on 4-Jan-2025

Summary

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Official Symbol
mat-3
Official Full Name
Cell division cycle protein 23 homolog
Primary source
WormBase:WBGene00003134
Locus tag
CELE_F10C5.1
See related
AllianceGenome:WB:WBGene00003134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable molecular adaptor activity. Involved in asymmetric cell division; polarity specification of anterior/posterior axis; and positive regulation of metaphase/anaphase transition of meiosis I. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mat-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (475454..482325)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MAGUK family Neighboring gene Nuclear envelope integral membrane protein Neighboring gene Ovule protein Neighboring gene YGGWG-amide

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and sequencing of temperature sensitive alleles of the Anaphase Promoting Complex component mat-3 in C. elegans. Maniates KA, et al. MicroPubl Biol, 2023. PMID 37614776, Free PMC Article
  2. The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix. Zhang Z, et al. J Mol Biol, 2013 Nov 15. PMID 23583778, Free PMC Article
  3. E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development. Kulkarni M, et al. PLoS Genet, 2008 Jul 18. PMID 18636104, Free PMC Article
  4. Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities. Shakes DC, et al. Development, 2003 Apr. PMID 12620985, Free PMC Article
  5. Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis. Stein KK, et al. Genetics, 2010 Dec. PMID 20944012, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SynMuv B genes suppress mat-3(ku233) defects by restoring mat-3 mRNA to wild-type levels.
    Title: Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in polarity specification of anterior/posterior axis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of metaphase/anaphase transition of meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cell division cycle protein 23 homolog
NP_497203.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    475454..482325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064802.7 → NP_497203.1  Cell division cycle protein 23 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497203.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19294
    Conserved Domains (2) summary
    sd00006
    Location:434 → 462
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:434 → 499
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19294.2

Gene LinkOut

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