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ace-4 Carboxylic ester hydrolase [ Caenorhabditis elegans ]

Gene ID: 175074, updated on 2-Nov-2024

Summary

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Official Symbol
ace-4
Official Full Name
Carboxylic ester hydrolase
Primary source
WormBase:WBGene00000038
Locus tag
CELE_Y48B6A.7
See related
AllianceGenome:WB:WBGene00000038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cholinesterase activity. Predicted to be active in extracellular space and plasma membrane. Is expressed in body wall musculature; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); drug dependence (multiple); myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ace-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
17
Sequence:
Chromosome: II; NC_003280.10 (14198046..14205460)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Carboxylic ester hydrolase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple ace genes encoding acetylcholinesterases of Caenorhabditis elegans have distinct tissue expression. Combes D, et al. Eur J Neurosci, 2003 Aug. PMID 12911746
  2. Acetylcholinesterase genes in the nematode Caenorhabditis elegans. Combes D, et al. Int Rev Cytol, 2001. PMID 11580201
  3. Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expression. Combes D, et al. J Mol Biol, 2000 Jul 21. PMID 10891266
  4. Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes. Bimonte M, et al. Eur J Neurosci, 2004 Sep. PMID 15355315
  5. Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle cells. Mörck C, et al. Dev Biol, 2006 Sep 15. PMID 16806153

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
NOT enables acetylcholinesterase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables cholinesterase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Carboxylic ester hydrolase
NP_496962.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14198046..14205460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064561.6 → NP_496962.1  Carboxylic ester hydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496962.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDN1
    Conserved Domains (2) summary
    COG0657
    Location:120 → 243
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:28 → 562
    COesterase; Carboxylesterase family
Nucleotide Protein
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