Y48E1B.3 Geranylgeranyl transferase type I subunit beta;Geranylgeranyl transferase type-1 subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y48E1B.3
Official Full Name: Geranylgeranyl transferase type I subunit beta;Geranylgeranyl transferase type-1 subunit beta
Primary source: WormBase:WBGene00013002
Locus tag: CELE_Y48E1B.3
See related: AllianceGenome:WB:WBGene00013002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly. Predicted to be active in fibrillar center. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y48E1B.3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (13547739..13567971, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48E1B.3 (e-PCR)
- UniSTS:322418

Y48E1B.4 (e-PCR)
- UniSTS:311197

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables CAAX-protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I core promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase I preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in fibrillar center	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Geranylgeranyl transferase type I subunit beta;Geranylgeranyl transferase type-1 subunit beta

NP_001254397.1

Confirmed by transcript evidence

NP_001254398.2

Partially confirmed by transcript evidence

NP_001254400.1

Confirmed by transcript evidence

NP_001367207.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13547739..13567971 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267468.4 → NP_001254397.1 Geranylgeranyl transferase type-1 subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254397.1

Status: REVIEWED

UniProtKB/TrEMBL

O18197

Conserved Domains (2) summary

COG5029
Location:30 → 354

CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]

cd02895
Location:29 → 332

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
NM_001267471.3 → NP_001254400.1 Geranylgeranyl transferase type I subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254400.1

Status: REVIEWED

UniProtKB/TrEMBL

B7WNB0

Conserved Domains (1) summary

cl08267
Location:1 → 167

ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
NM_001267469.4 → NP_001254398.2 Geranylgeranyl transferase type I subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

B7WNB1
NM_001381645.1 → NP_001367207.1 Geranylgeranyl transferase type I subunit beta [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

B7WNB2