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hpr-17 uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 174958, updated on 2-Nov-2024

Summary

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Official Symbol
hpr-17
Official Full Name
uncharacterized protein
Primary source
WormBase:WBGene00001998
Locus tag
CELE_F32A11.2
See related
AllianceGenome:WB:WBGene00001998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA damage checkpoint signaling; DNA repair; and mitotic DNA replication checkpoint signaling. Predicted to be located in nucleus. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hpr-17 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (13153464..13157047, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MLt-TeN (mlt-10) related Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Mitochondrial import inner membrane translocase subunit Tim21 Neighboring gene CCCH-type zinc finger protein moe-3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication. Boerckel J, et al. Genetics, 2007 May. PMID 17339221, Free PMC Article
  2. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. Dean FB, et al. Genomics, 1998 Dec 15. PMID 9878245
  3. The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. Bailly AP, et al. PLoS Genet, 2010 Jul 15. PMID 20661466, Free PMC Article
  4. Death and more: DNA damage response pathways in the nematode C. elegans. Stergiou L, et al. Cell Death Differ, 2004 Jan. PMID 14685168
  5. Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Hofmann ER, et al. Curr Biol, 2002 Nov 19. PMID 12445383

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hpr-17 defines an replication factor C-like complex that facilitates telomerase activity in vivo in C. elegans.
    Title: The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_496793.1
  • Product from WormBase gene class hpr;
    Confirmed by transcript evidence; Homolog of S. Pombe Rad

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13153464..13157047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064392.7 → NP_496793.1  uncharacterized protein CELE_F32A11.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGG2
    Conserved Domains (2) summary
    pfam03215
    Location:15 → 375
    Rad17; Rad17 cell cycle checkpoint protein
    pfam13191
    Location:28 → 153
    AAA_16; AAA ATPase domain
Nucleotide Protein
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