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ash-2 B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 [ Caenorhabditis elegans ]

Gene ID: 174838, updated on 2-Nov-2024

Summary

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Official Symbol
ash-2
Official Full Name
B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2
Primary source
WormBase:WBGene00012458
Locus tag
CELE_Y17G7B.2
See related
AllianceGenome:WB:WBGene00012458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription cis-regulatory region binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in nucleus. Part of MLL3/4 complex. Is expressed in germ line. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ash-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (11979838..11989050)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BZIP domain-containing protein;Regulator of rDNA transcription 14 Neighboring gene BZIP domain-containing protein Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene Deoxyhypusine synthase Neighboring gene Activin_recp domain-containing protein;DUF281 domain-containing protein Neighboring gene DNA replication licensing factor MCM2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenerational lipid-reducing activity of benzylisoquinoline alkaloids in Caenorhabditis elegans. Chow YL, et al. Genes Cells, 2019 Jan. PMID 30451341
  2. Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans. Nono M, et al. Cell Rep, 2020 Mar 10. PMID 32160530
  3. Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism. Shrestha B, et al. Cell Stress Chaperones, 2024 Jun. PMID 38608859, Free PMC Article
  4. Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells. Xiao Y, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21527717, Free PMC Article
  5. The SET-2/SET1 histone H3K4 methyltransferase maintains pluripotency in the Caenorhabditis elegans germline. Robert VJ, et al. Cell Rep, 2014 Oct 23. PMID 25310986

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In AIB interneurons, NPR-4 was involved in the control of preference choice by activating the functions of ASH-2 trithorax complex consisting of SET-2, ASH-2, and WDR-5, implying the crucial role of molecular machinery of trimethylation of histone H3K4 in the preference choice control.
    Title: FLP-4 neuropeptide and its receptor in a neuronal circuit regulate preference choice through functions of ASH-2 trithorax complex in Caenorhabditis elegans.
  2. SET-2 is responsible for the majority of bulk H3K4 methylation at all developmental stages
    Title: Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transdifferentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2
NP_001317781.1
  • Confirmed by transcript evidence
NP_001359515.1
  • Confirmed by transcript evidence
NP_001360415.1
  • Confirmed by transcript evidence
NP_496555.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11979838..11989050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373799.3 → NP_001359515.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXH4
    Conserved Domains (3) summary
    cd15583
    Location:21 → 75
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:314 → 512
    SPRY_Ash2; SPRY domain in Ash2
    pfam12005
    Location:169 → 221
    DUF3499; Protein of unknown function (DUF3499)

  2. NM_064154.3 → NP_496555.1  Set1/Ash2 histone methyltransferase complex subunit ash-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496555.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFZ3
    Conserved Domains (2) summary
    cd15583
    Location:21 → 73
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:312 → 510
    SPRY_Ash2; SPRY domain in Ash2

  3. NM_001330962.4 → NP_001317781.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168H2F9
    Conserved Domains (3) summary
    cd15583
    Location:21 → 73
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:315 → 513
    SPRY_Ash2; SPRY domain in Ash2
    pfam12005
    Location:167 → 219
    DUF3499; Protein of unknown function (DUF3499)

  4. NM_001373798.2 → NP_001360415.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168H287
    Conserved Domains (3) summary
    cd15583
    Location:21 → 75
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:317 → 515
    SPRY_Ash2; SPRY domain in Ash2
    pfam12005
    Location:169 → 221
    DUF3499; Protein of unknown function (DUF3499)

RNA

  1. NR_138517.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFZ3.1

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