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tars-1 Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 174790, updated on 2-Nov-2024

Summary

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Official Symbol
tars-1
Official Full Name
Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase
Primary source
WormBase:WBGene00006617
Locus tag
CELE_C47D12.6
See related
AllianceGenome:WB:WBGene00006617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable threonine-tRNA ligase activity. Involved in determination of adult lifespan. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in anal depressor muscle; body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tars-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (11691325..11694293, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ERCC4 domain-containing protein Neighboring gene inositol-3-phosphate synthase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial translational defect extends lifespan in C. elegans by activating UPR(mt). Guo M, et al. Redox Biol, 2023 Jul. PMID 37167879, Free PMC Article
  2. Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans. Hanazawa M, et al. Proc Natl Acad Sci U S A, 2001 Jul 17. PMID 11447255, Free PMC Article
  3. Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation. Itani OA, et al. Curr Biol, 2021 Jan 11. PMID 33157031, Free PMC Article
  4. Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Maeda I, et al. Curr Biol, 2001 Feb 6. PMID 11231151
  5. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Chen D, et al. Aging Cell, 2007 Aug. PMID 17521386, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase
NP_001022033.1
  • Confirmed by transcript evidence
NP_001379393.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11691325..11694293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026862.7 → NP_001022033.1  Threonine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022033.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52709
    Conserved Domains (5) summary
    cd01667
    Location:82 → 143
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:46 → 714
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:249 → 296
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:320 → 617
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:617 → 708
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

  2. NM_001393202.1 → NP_001379393.1  threonine--tRNA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86D21
    Conserved Domains (1) summary
    PLN02908
    Location:5 → 673
    PLN02908; threonyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52709.1

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